HYBRID EVENT: You can participate in person at Tokyo, Japan or Virtually from your home or work.

3rd Edition of
World Aquaculture and Fisheries Conference

May 24-25, 2023| Hybrid Event
WAC 2022

How fish color their skin? MC2R a new actor in pigmentation development

Priyanka Soni, Speaker at Aquaculture Conferences 2022
University of Southern California, United States
Title : How fish color their skin? MC2R a new actor in pigmentation development


The melanocortin system is a complex neuroendocrine signalling mechanism involved in numerous physiological processes in vertebrates, including pigmentation, steroidogenesis and metabolic control. In humans, five melanocortin receptors (MCR) have been cloned, identified and shown to have a wide distribution throughout the body and likely many diverse functions. It has also been shown that a high degree of identity and conservation in structural characteristics and pharmacology exists between Mcrs from fish and mammals. However, in fishes, the number, affinity, specificity, tissue distribution and physiological roles are far from defined and appear to be species-specific. A clear example is the Mc2r subtype. In humans, it is well known that Mc2r is expressed in the adrenal gland and controls steroidogenesis and in fact the same function has also been described in fish. However, the fact that Acth (a melanocortin agonist) may have a role in regulating fish pigmentation and that Acth acts on Mc2r, the involvement of Mc2r in fish pigmentation might be a possibility. Using CRISPR/Cas9 genome engineering tools we have generated “loss-of-function” mc2r mutant zebrafish. We demonstrate that Mc2r, apart from controlling steroidogenesis, also has a direct role in regulating fish pigmentation.



Priyanka soni studied Marine Environment and Resources at University of Basque country and currently pursuing her Ph.D. in University of Southern California in department of earth science. She received her master’s degree in 2021. During her master’s thesis she worked in supervision of Dr. Josep Rotllant at the Institute of marine research (IIM – CSIC, Spain) on abnormalities in fish pigmentation due to environmental stress conditions. Her interest areas are epigenetics, climate effects and biochemistry. This research work will be going to publish in Frontiers in Endocrinology.