Aquaculture disease resistance involves breeding or developing fish that are less susceptible to diseases, which is crucial for maintaining the health and productivity of fish farms. Selective breeding programs focus on enhancing the immune response of fish, while innovations in genetics allow for the identification and development of disease-resistant strains. This reduces the need for antibiotics and chemicals, leading to more sustainable and eco-friendly practices. Disease-resistant fish help prevent major economic losses caused by infections and improve overall farm efficiency. Research into vaccine development and fish immunology continues to expand the options available for combating diseases in aquaculture.