Stress in aquatic organisms, such as fish and shellfish, is a significant challenge in aquaculture. Environmental factors like temperature changes, water pollution, and overcrowding can induce physiological stress, which weakens the immune system and increases vulnerability to diseases. Understanding these stress responses is crucial for improving welfare and optimizing farm conditions. Stress indicators, including elevated cortisol levels and changes in behavior, can be monitored to assess fish health. By maintaining stable water quality, reducing stocking densities, and optimizing feeding practices, stress can be minimized, promoting better growth and resistance to disease. Incorporating stress management techniques in aquaculture can enhance the sustainability and profitability of the industry by improving the health and productivity of farmed species.