Biotechnology in aquaculture encompasses genetic engineering, microbial management, and bioinformatics to improve fish production, health, and sustainability. Genetic tools enable selective breeding, producing fish with improved growth rates, disease resistance, and environmental adaptability. Additionally, biotechnology aids in developing diagnostic kits for early disease detection, enhancing biosecurity measures. Probiotics and prebiotics, products of biotechnological research, improve fish digestion and immunity, reducing reliance on antibiotics. Moreover, bioengineering is applied to design environmentally friendly aquaculture systems that optimize resource use and minimize waste. Overall, biotechnology empowers aquaculture to meet growing seafood demands while promoting ecological balance.