Disease control is a critical aspect of maintaining health in aquaculture systems. Aquatic species are vulnerable to various pathogens, including bacteria, viruses, and parasites, which can spread rapidly in confined environments. Effective disease management involves maintaining optimal water quality, regular monitoring of fish health, and implementing biosecurity protocols to prevent pathogen introduction. Vaccination programs and disease-resistant breeding are also used to improve disease control. Research into probiotics, alternative medicines, and integrated pest management strategies offers further solutions to minimize reliance on antibiotics and reduce environmental impact. Sustainable disease control practices are essential for the long-term success of aquaculture.