Shellfish immunology focuses on the study of the immune systems of shellfish species such as oysters, mussels, and clams. Shellfish farming faces numerous challenges, including diseases that affect productivity and product quality. Understanding the immune response of shellfish to pathogens, environmental stressors, and pollutants is crucial for developing better management practices. By exploring immune functions such as cellular responses, antimicrobial peptides, and genetic factors, researchers aim to improve disease resistance and support sustainable aquaculture practices. Advances in shellfish immunology are vital for enhancing the resilience of shellfish populations, reducing the need for antibiotics, and ensuring the safety of seafood for consumers.