Aquaculture Antibiotics, integral components of modern aquaculture practices, play a pivotal role in maintaining the health and productivity of farmed aquatic organisms. As the demand for seafood escalates globally, aquaculture has become a crucial source of fish and shellfish, but its success is often challenged by the threat of bacterial infections and diseases. Antibiotics in aquaculture serve as therapeutic agents, prophylactics, and growth promoters, aiding in the prevention and treatment of bacterial infections that can devastate fish and shrimp populations. These antibiotics are administered through feed, water, or injections, targeting specific pathogens while promoting the overall well-being of the aquatic species. However, the use of aquaculture antibiotics is a subject of ongoing debate and scrutiny due to concerns about antibiotic resistance, environmental impact, and potential residues in seafood consumed by humans. Efforts are underway to develop sustainable and responsible aquaculture practices, including the judicious use of antibiotics, alternative disease management strategies, and the implementation of stringent regulations to mitigate the risks associated with their use. Balancing the need for disease control with environmental and human health considerations is imperative for the future sustainability of aquaculture and the global seafood supply.